Red List

UPBUpstream Bio, Inc.

Healthcare · Biotechnology · small-cap ($414M)
-75.3%
from rolling 252-day high of $33.68 set 2026-01-14 · 134d ago
Current
$8.32
Decline depth
-75.3%
Decline σ
4.9σ
TFC
4/5 bearish
Rolling 252-day high Up day Down day Last 90 trading days · data from Alpaca

Since tracking began

$UPB has been tracked since 2026-03-01. It was down 77.1% from its 52-week high then — now down -75.3%.

That's 4.8 percentage points deeper than the day it joined.

Decline from the 52-week high as it stood on 2026-03-02 (fixed anchor) → today. Split-adjusted, Alpaca. Observed history, not a forecast.

Structural break signals

UPB qualifies for the Red List on decline depth.

Decline depth
-75.3%
From rolling 252-day high of $33.68, 134d ago. Past the 40% Red List threshold.
Time-frame continuity
4/5 bearish
Latest bar across daily/weekly/monthly/quarterly/yearly time frames. A bar counts as bearish when it's a 2-Down or a red 3. Past the 4/5 Amber threshold.
Decline sigma
4.9σ
Drop from local high over the last 20 bars, expressed in units of the stock's typical daily volatility (3.14% per day). Past the ≥4σ Watch threshold.

The structural read

What price action says about UPB.

UPB qualifies for the Red List on decline depth — down -75.3% from its rolling 252-day high. Past the 40% threshold, the deepest tier in the taxonomy.

Cross-confirmation: also showing 4/5 bearish time frames.

Cross-confirmation: decline sigma also reads 4.9σ over 20 bars.

Upstream TFC read: weak alignment, current phase daily. Last bar types — daily 2D (green), weekly 1 (red), monthly 2D (red).

52-week range

52W low $5.14 11.1% of range 52W high $33.68

Sector context · Healthcare

194 other Healthcare tickers are on Broken Stocks.

88 Red List
47 Amber
59 Watch
-35.8% Median decline

Worst in sector: OPRX (-77.1%). Least-bad: MRNA (-20.1%). See all Healthcare listings →

Questions about UPB

What people ask.

Why is UPB on Broken Stocks?

UPB qualifies for the Red List on decline depth. It is down -75.3% from its rolling 252-day high of $33.68, set on 2026-01-14 — 134d ago.

Is UPB a falling knife?

Not by the strict technical definition. UPB is down -75.3% from its 52-week high, but that high was set 134d ago — more than 120 days. A falling knife is usually a recent breakdown from a fresh high, not an established multi-quarter downtrend. UPB is still on the Red List for decline depth, but the freshness component of a falling knife is missing.

Is UPB a buy?

Broken Stocks does not issue buy or sell recommendations. The list is a rules-based technical warning system. It tracks structural decline depth and recency — not company quality, management, fundamentals, or news. Always do your own research and consult a licensed advisor.

Where is UPB trading inside its 52-week range?

At $8.32, UPB sits 11.1% of the way from its 52-week low ($5.14) to its 52-week high ($33.68). A reading below 25% indicates price is hugging the bottom of the range; above 75%, the top.

How fast has UPB been declining?

The current 75.3% decline accrued over 134d, which annualizes to roughly -205.1% per year. Annualized pace is a sanity check — a 30% decline in three months is a different signal than a 30% decline over two years.

How does UPB compare to its sector?

There are 194 other Healthcare tickers on Broken Stocks: 88 Red, 47 Amber, 59 Watch, with 108 showing recovering structural signals. Median sector decline is -35.8% — UPB's decline is deeper than the sector median.