The Broken Stocks list · updated 2026-08-20
2,559 U.S. stocks down 20% or more from a 52-week high.
Falling knives, broken trends, and Watch-tier early declines. Filter by tier, sector, or ticker. Tiering is computed daily from decline depth, time-frame continuity, and decline sigma.
| Tier | Ticker | Company | Decline | Sigma | TFC | Days | Price | Trigger |
|---|---|---|---|---|---|---|---|---|
| Red List |  UPB |
Upstream Bio, Inc. · Healthcare | -79.7% | 3.0σ | 4/5 | 218d | $6.85 | Depth |
| Red List |  KRRO |
Korro Bio, Inc. · Healthcare | -76.8% | 2.3σ | 2/5 | 308d | $12.96 | Depth |
| Red List |  WVE |
Wave Life Sciences Ltd. · Healthcare | -75.8% | 3.9σ | 3/5 | 254d | $5.25 | Depth |
| Red List |  MLTX |
MoonLake Immunotherapeutics · Healthcare | -74.7% | 6.4σ | 1/5 | 328d | $15.87 | Depth |
| Red List |  EYPT |
EyePoint, Inc. · Healthcare | -71.8% | 3.8σ | 3/5 | 255d | $5.39 | Depth |
| Red List |  OLMA |
Olema Pharmaceuticals, Inc. · Healthcare | -69.9% | 3.6σ | 3/5 | 247d | $10.90 | Depth |
| Red ListRecovering |  DOCS |
Doximity, Inc. · Healthcare | -66.1% | 4.6σ | 3/5 | 325d | $25.94 | Depth |
| Red ListRecovering |  LYEL |
Lyell Immunopharma, Inc. · Healthcare | -65.9% | 3.1σ | 2/5 | 241d | $15.33 | Depth |
| Red ListRecovering |  EMBC |
Embecta Corp. · Healthcare | -64.9% | 0.8σ | 4/5 | 337d | $5.46 | Depth |
| Red List |  OPRX |
OptimizeRx Corporation · Healthcare | -64.4% | 2.1σ | 2/5 | 297d | $7.93 | Depth |
| Red List |  SPRY |
ARS Pharmaceuticals, Inc. · Healthcare | -63.5% | 2.8σ | 3/5 | 364d | $5.50 | Depth |
| Red ListRecovering |  PHR |
Phreesia, Inc. · Healthcare | -63.4% | 2.8σ | 4/5 | 357d | $12.00 | Depth |
| Red List |  BIOA |
BioAge Labs, Inc. · Healthcare | -62.7% | 3.9σ | 3/5 | 45d | $9.69 | Depth |
| Red ListRecovering |  OCS |
Oculis Holding AG · Healthcare | -61.9% | 2.4σ | 3/5 | 101d | $13.12 | Depth |
| Red List |  DNA |
Ginkgo Bioworks Holdings, Inc. · Healthcare | -60.4% | 4.1σ | 2/5 | 316d | $6.96 | Depth |
| Red List |  ATEC |
Alphatec Holdings, Inc. · Healthcare | -60.1% | 3.0σ | 4/5 | 224d | $9.29 | Depth |
| Red List |  AHCO |
AdaptHealth Corp. · Healthcare | -59.9% | 5.8σ | 0/5 | 108d | $5.39 | Depth |
| Red List |  SMMT |
Summit Therapeutics Inc. · Healthcare | -58.6% | 5.1σ | 3/5 | 359d | $12.43 | Depth |
| Red List |  PODD |
Insulet Corporation · Healthcare | -58.6% | 2.9σ | 4/5 | 273d | $146.95 | Depth |
| Red ListRecovering |  INSP |
Inspire Medical Systems, Inc. · Healthcare | -58.3% | 2.1σ | 5/5 | 253d | $61.27 | Depth |
| Red List |  QDEL |
QuidelOrtho Corporation · Healthcare | -58.3% | 3.3σ | 3/5 | 216d | $14.85 | Depth |
| Red List |  NTLA |
Intellia Therapeutics, Inc. · Healthcare | -56.0% | 1.8σ | 2/5 | 304d | $12.44 | Depth |
| Red List |  CING |
Cingulate Inc. · Healthcare | -55.2% | 2.5σ | 2/5 | 156d | $5.33 | Depth |
| Red List |  BSX |
Boston Scientific Corporation · Healthcare | -54.9% | 3.2σ | 5/5 | 345d | $49.37 | Depth |
| Red ListRecovering |  ARCT |
Arcturus Therapeutics Holdings · Healthcare | -54.5% | 1.6σ | 2/5 | 303d | $10.99 | Depth |
| Red List |  RXST |
RxSight, Inc. · Healthcare | -53.9% | 4.4σ | 5/5 | 252d | $6.09 | Depth |
| Red List |  TRDA |
Entrada Therapeutics, Inc. · Healthcare | -53.8% | 1.9σ | 2/5 | 106d | $7.60 | Depth |
| Red ListRecovering |  ALNY |
Alnylam Pharmaceuticals, Inc. · Healthcare | -53.7% | 2.9σ | 3/5 | 304d | $229.30 | Depth |
| Red List |  ZTS |
Zoetis Inc. · Healthcare | -53.2% | 2.5σ | 5/5 | 365d | $75.02 | Depth |
| Red List |  PHAT |
Phathom Pharmaceuticals, Inc. · Healthcare | -53.0% | 5.1σ | 4/5 | 240d | $8.60 | Depth |
| Red List |  ALGS |
Aligos Therapeutics, Inc. · Healthcare | -53.0% | 1.9σ | 2/5 | 248d | $6.44 | Depth |
| Red ListRecovering |  ADMA |
ADMA Biologics Inc · Healthcare | -52.3% | 2.0σ | 5/5 | 251d | $9.76 | Depth |
| Red List |  CRBP |
Corbus Pharmaceuticals Holdings · Healthcare | -52.1% | 3.2σ | 2/5 | 304d | $9.84 | Depth |
| Red List |  STRO |
Sutro Biopharma, Inc. · Healthcare | -51.7% | 4.5σ | 1/5 | 97d | $21.17 | Depth |
| Red ListRecovering |  WGS |
GeneDx Holdings Corp. · Healthcare | -51.7% | 1.5σ | 4/5 | 261d | $82.62 | Depth |
| Red List |  KROS |
Keros Therapeutics, Inc. · Healthcare | -51.4% | 2.3σ | 2/5 | 255d | $10.95 | Depth |
| Red ListRecovering |  HIMS |
Hims & Hers Health, Inc. · Healthcare | -51.2% | 1.5σ | 4/5 | 309d | $31.86 | Depth |
| Red List |  PRCT |
PROCEPT BioRobotics Corporation · Healthcare | -51.1% | 2.5σ | 3/5 | 352d | $20.74 | Depth |
| Red ListRecovering |  JANX |
Janux Therapeutics, Inc. · Healthcare | -51.1% | 1.2σ | 4/5 | 267d | $17.28 | Depth |
| Red List |  CLPT |
ClearPoint Neuro Inc. · Healthcare | -49.5% | 1.2σ | 3/5 | 315d | $15.19 | Depth |
| Red List |  CRVS |
Corvus Pharmaceuticals, Inc. · Healthcare | -46.8% | 3.3σ | 2/5 | 209d | $14.33 | Depth |
| Red List |  MLYS |
Mineralys Therapeutics, Inc. · Healthcare | -46.0% | 5.2σ | 4/5 | 281d | $25.75 | Depth |
| Red List |  CUE |
Cue Biopharma, Inc. · Healthcare | -45.9% | 4.0σ | 1/5 | 41d | $24.61 | Depth |
| Red List |  VNDA |
Vanda Pharmaceuticals Inc. · Healthcare | -45.9% | 1.8σ | 2/5 | 163d | $5.38 | Depth |
| Red List |  COLL |
Collegium Pharmaceutical, Inc. · Healthcare | -45.8% | 4.9σ | 3/5 | 234d | $27.54 | Depth |
| Red ListRecovering |  CRMD |
CorMedix Inc. · Healthcare | -45.0% | 1.9σ | 2/5 | 356d | $8.23 | Depth |
| Red List |  VERA |
Vera Therapeutics, Inc. · Healthcare | -44.2% | 4.3σ | 2/5 | 239d | $31.26 | Depth |
| Red ListRecovering |  VTYX |
Ventyx Biosciences, Inc. · Healthcare | -44.0% | — | 0/5 | 226d | $14.00 | Depth |
| Red List |  GLUE |
Monte Rosa Therapeutics, Inc. · Healthcare | -42.6% | 5.8σ | 3/5 | 224d | $14.78 | Depth |
| Red List |  SGRY |
Surgery Partners, Inc. · Healthcare | -42.2% | 5.4σ | 3/5 | 364d | $13.94 | Depth |
| Red List |  AORT |
Artivion, Inc. · Healthcare | -42.0% | 2.8σ | 3/5 | 246d | $27.98 | Depth |
| Red ListRecovering |  TMDX |
TransMedics Group, Inc. · Healthcare | -41.8% | 1.4σ | 3/5 | 261d | $90.85 | Depth |
| Red ListRecovering |  SLNO |
Soleno Therapeutics, Inc. · Healthcare | -41.3% | — | 5/5 | 407d | $53.01 | Depth |
| Red List |  PAHC |
Phibro Animal Health Corporatio · Healthcare | -41.2% | 4.9σ | 0/5 | 129d | $35.18 | Depth |
| Red List |  INSM |
Insmed Incorporated · Healthcare | -41.2% | 1.2σ | 3/5 | 261d | $125.09 | Depth |
| Red List |  OFIX |
Orthofix Medical Inc. · Healthcare | -41.1% | 4.8σ | 3/5 | 289d | $10.00 | Depth |
| Red ListRecovering |  PRGO |
Perrigo Company plc · Healthcare | -40.9% | 0.6σ | 3/5 | 363d | $13.70 | Depth |
| Red ListRecovering |  WAY |
Waystar Holding Corp. · Healthcare | -40.1% | 1.0σ | 4/5 | 345d | $24.84 | Depth |
| Red List |  CELC |
Celcuity Inc. · Healthcare | -40.0% | 1.7σ | 2/5 | 108d | $90.57 | Depth |
| Red List |  RARE |
Ultragenyx Pharmaceutical Inc. · Healthcare | -36.5% | 4.5σ | 5/5 | 255d | $25.32 | TFC |
| Red List |  INBX |
Inhibrx Biosciences, Inc. · Healthcare | -36.1% | 1.4σ | 3/5 | 120d | $99.15 | Depth |
| Red List |  STAA |
STAAR Surgical Company · Healthcare | -35.7% | 3.5σ | 2/5 | 98d | $23.07 | Depth |
| Red List |  TDOC |
Teladoc Health, Inc. · Healthcare | -34.4% | 4.5σ | 2/5 | 35d | $6.49 | Depth |
| Red ListRecovering |  NAMS |
NewAmsterdam Pharma Company N.V · Healthcare | -34.2% | 4.6σ | 1/5 | 101d | $27.81 | Depth |
| Red ListRecovering |  QTTB |
Q32 Bio Inc. · Healthcare | -32.7% | 2.4σ | 0/5 | 37d | $15.86 | Depth |
| Red List |  TNGX |
Tango Therapeutics, Inc. · Healthcare | -31.6% | 6.5σ | 1/5 | 64d | $23.52 | Depth |
| Red ListRecovering |  VCYT |
Veracyte, Inc. · Healthcare | -31.4% | 5.5σ | 2/5 | 51d | $41.79 | Depth |
| Red List |  BKD |
Brookdale Senior Living Inc. · Healthcare | -30.9% | 8.8σ | 2/5 | 184d | $11.81 | Sigma |
| Red List |  AGL |
agilon health, inc. · Healthcare | -30.3% | 2.9σ | 3/5 | 34d | $92.73 | Depth |
| Red List |  PRVA |
Privia Health Group, Inc. · Healthcare | -26.4% | 8.1σ | 4/5 | 35d | $21.20 | Sigma |
| Amber ListRecovering |  IRTC |
iRhythm Holdings, Inc. · Healthcare | -39.6% | 2.5σ | 3/5 | 293d | $127.95 | Depth |
| Amber List |  INGN |
Inogen, Inc · Healthcare | -38.7% | 7.5σ | 2/5 | 302d | $5.60 | Depth |
| Amber List |  ISRG |
Intuitive Surgical, Inc. · Healthcare | -38.0% | 2.9σ | 2/5 | 225d | $374.48 | Depth |
| Amber List |  TCMD |
Tactile Systems Technology, Inc · Healthcare | -38.0% | 5.4σ | 1/5 | 183d | $23.43 | Depth |
| Amber ListRecovering |  ARVN |
Arvinas, Inc. · Healthcare | -37.8% | 1.9σ | 3/5 | 163d | $9.03 | Depth |
| Amber List |  DMAC |
DiaMedica Therapeutics Inc. · Healthcare | -37.4% | 4.5σ | 2/5 | 253d | $6.52 | Depth |
| Amber ListRecovering |  CERT |
Certara, Inc. · Healthcare | -37.1% | 2.2σ | 4/5 | 321d | $8.73 | Depth |
| Amber ListRecovering |  IBRX |
ImmunityBio, Inc. · Healthcare | -36.9% | 1.8σ | 2/5 | 176d | $7.84 | Depth |
| Amber List |  TYRA |
Tyra Biosciences, Inc. · Healthcare | -36.8% | 4.5σ | 1/5 | 141d | $25.69 | Depth |
| Amber List |  SPOK |
Spok Holdings, Inc. · Healthcare | -36.4% | 5.8σ | 3/5 | 367d | $10.43 | Depth |
| Amber ListRecovering |  OPCH |
Option Care Health, Inc. · Healthcare | -36.2% | 3.1σ | 2/5 | 209d | $23.49 | Depth |
| Amber ListRecovering |  TEM |
Tempus AI, Inc. · Healthcare | -36.1% | 1.5σ | 2/5 | 315d | $66.63 | Depth |
| Amber ListRecovering |  FLGT |
Fulgent Genetics, Inc. · Healthcare | -35.8% | 0.9σ | 3/5 | 268d | $19.92 | Depth |
| Amber List |  OMCL |
Omnicell, Inc. · Healthcare | -35.5% | 5.7σ | 1/5 | 219d | $35.50 | Depth |
| Amber ListRecovering |  GRAL |
GRAIL, Inc. · Healthcare | -34.4% | 1.6σ | 2/5 | 210d | $77.97 | Depth |
| Amber List |  TLSI |
TriSalus Life Sciences, Inc. · Healthcare | -34.2% | 2.6σ | 3/5 | 241d | $5.23 | Depth |
| Amber ListRecovering |  OCUL |
Ocular Therapeutix, Inc. · Healthcare | -32.5% | 1.7σ | 3/5 | 255d | $11.09 | Depth |
| Amber List |  ARDT |
Ardent Health, Inc. · Healthcare | -32.3% | 4.9σ | 3/5 | 295d | $10.48 | Depth |
| Amber ListRecovering |  IONS |
Ionis Pharmaceuticals, Inc. · Healthcare | -32.3% | 1.9σ | 3/5 | 196d | $58.76 | Depth |
| Amber List |  RGNX |
REGENXBIO Inc. · Healthcare | -31.7% | 2.0σ | 3/5 | 210d | $11.06 | Depth |
| Amber ListRecovering |  QURE |
uniQure N.V. · Healthcare | -31.6% | 1.7σ | 2/5 | 296d | $48.90 | Depth |
| Amber List |  IMTX |
Immatics N.V. · Healthcare | -31.1% | 4.7σ | 2/5 | 259d | $8.55 | Depth |
| Amber ListRecovering |  AMPH |
Amphastar Pharmaceuticals, Inc. · Healthcare | -30.6% | 2.7σ | 4/5 | 352d | $21.68 | Depth |
| Amber List |  LMAT |
LeMaitre Vascular, Inc. · Healthcare | -30.1% | 3.8σ | 0/5 | 128d | $82.32 | Depth |
| Amber ListRecovering |  UHS |
Universal Health Services, Inc. · Healthcare | -29.6% | 2.6σ | 4/5 | 267d | $172.87 | TFC |
| Amber List |  IDXX |
IDEXX Laboratories, Inc. · Healthcare | -29.1% | 6.9σ | 4/5 | 267d | $545.86 | TFC |
| Amber List |  ALMS |
Alumis Inc. · Healthcare | -27.1% | 6.1σ | 3/5 | 43d | $22.86 | Sigma |
| Amber List |  XRAY |
DENTSPLY SIRONA Inc. · Healthcare | -27.0% | 7.6σ | 1/5 | 174d | $10.78 | Sigma |
| Amber ListRecovering |  CRSP |
CRISPR Therapeutics AG · Healthcare | -25.9% | 1.8σ | 4/5 | 316d | $58.12 | TFC |
| Amber List |  ASTH |
Astrana Health Inc. · Healthcare | -24.9% | 2.1σ | 4/5 | 49d | $38.74 | TFC |
| Amber List |  ACHC |
Acadia Healthcare Company, Inc. · Healthcare | -24.7% | 4.8σ | 4/5 | 29d | $26.97 | TFC |
| Amber ListRecovering |  QGEN |
Qiagen N.V. · Healthcare | -21.6% | 1.6σ | 4/5 | 212d | $44.90 | TFC |
| Amber List |  PGNY |
Progyny, Inc. · Healthcare | -21.5% | 7.2σ | 3/5 | 35d | $25.96 | Sigma |
| Amber List |  ALGN |
Align Technology, Inc. · Healthcare | -20.7% | 6.1σ | 1/5 | 121d | $158.94 | Sigma |
| Amber List |  ARQT |
Arcutis Biotherapeutics, Inc. · Healthcare | -20.2% | 6.2σ | 3/5 | 255d | $25.35 | Sigma |
| Watch |  NUVB |
Nuvation Bio Inc. · Healthcare | -29.9% | 2.6σ | 2/5 | 241d | $6.83 | Depth |
| WatchRecovering |  NVAX |
Novavax, Inc. · Healthcare | -29.7% | 2.9σ | 0/5 | 175d | $8.42 | Depth |
| Watch |  ERAS |
Erasca, Inc. · Healthcare | -29.6% | 5.8σ | 1/5 | 119d | $17.08 | Depth |
| WatchRecovering |  ZBIO |
Zenas BioPharma, Inc. · Healthcare | -29.1% | 3.5σ | 1/5 | 239d | $31.62 | Depth |
| Watch |  PBH |
Prestige Consumer Healthcare In · Healthcare | -28.9% | 4.5σ | 2/5 | 177d | $50.52 | Depth |
| WatchRecovering |  VRDN |
Viridian Therapeutics, Inc. · Healthcare | -28.6% | 1.1σ | 3/5 | 218d | $24.50 | Depth |
| Watch |  NPCE |
Neuropace, Inc. · Healthcare | -28.4% | 3.5σ | 2/5 | 104d | $14.03 | Depth |
| Watch |  NVO |
Novo Nordisk A/S · Healthcare | -28.1% | 3.9σ | 3/5 | 209d | $46.14 | Depth |
| Watch |  ANNX |
Annexon, Inc. · Healthcare | -27.9% | 3.1σ | 2/5 | 209d | $5.18 | Depth |
| Watch |  BHVN |
Biohaven Ltd. · Healthcare | -27.3% | 3.8σ | 3/5 | 294d | $13.50 | Depth |
| Watch |  AGIO |
Agios Pharmaceuticals, Inc. · Healthcare | -26.9% | 4.1σ | 2/5 | 275d | $33.63 | Depth |
| WatchRecovering |  HCA |
HCA Healthcare, Inc. · Healthcare | -26.7% | 2.0σ | 3/5 | 161d | $406.27 | Depth |
| WatchRecovering |  BEAM |
Beam Therapeutics Inc. · Healthcare | -25.8% | 2.0σ | 3/5 | 44d | $28.39 | Depth |
| WatchRecovering |  CSTL |
Castle Biosciences, Inc. · Healthcare | -25.6% | 1.1σ | 2/5 | 206d | $32.93 | Depth |
| Watch |  MIRM |
Mirum Pharmaceuticals, Inc. · Healthcare | -25.3% | 4.4σ | 3/5 | 42d | $97.18 | Depth |
| Watch |  JBIO |
Jade Biosciences, Inc. · Healthcare | -24.2% | 4.4σ | 3/5 | 115d | $21.23 | Depth |
| WatchRecovering |  SRPT |
Sarepta Therapeutics, Inc. · Healthcare | -24.1% | 2.2σ | 1/5 | 316d | $19.22 | Depth |
| Watch |  TNDM |
Tandem Diabetes Care, Inc. · Healthcare | -23.9% | 2.1σ | 1/5 | 177d | $22.57 | Depth |
| Watch |  ENOV |
Enovis Corporation · Healthcare | -23.6% | 3.7σ | 3/5 | 297d | $26.18 | Depth |
| Watch |  NBTX |
Nanobiotix S.A. · Healthcare | -23.6% | 1.4σ | 2/5 | 98d | $43.68 | Depth |
| Watch |  PRTA |
Prothena Corporation plc · Healthcare | -23.5% | 2.8σ | 2/5 | 104d | $9.03 | Depth |
| Watch |  ENTA |
Enanta Pharmaceuticals, Inc. · Healthcare | -23.4% | 3.3σ | 3/5 | 234d | $13.13 | Depth |
| Watch |  SNN |
Smith & Nephew SNATS, Inc. · Healthcare | -23.4% | 5.4σ | 2/5 | 345d | $29.04 | Depth |
| Watch |  AUNA |
Auna SA · Healthcare | -23.4% | 4.5σ | 2/5 | 322d | $5.25 | Depth |
| WatchRecovering |  HROW |
Harrow, Inc. · Healthcare | -23.3% | 1.4σ | 1/5 | 225d | $42.06 | Depth |
| Watch |  ABSI |
Absci Corporation · Healthcare | -23.0% | 1.4σ | 1/5 | 52d | $9.28 | Depth |
| WatchRecovering |  SNDX |
Syndax Pharmaceuticals, Inc. · Healthcare | -22.8% | 3.3σ | 1/5 | 148d | $19.75 | Depth |
| Watch |  PTCT |
PTC Therapeutics, Inc. · Healthcare | -22.4% | 3.9σ | 3/5 | 42d | $70.52 | Depth |
| Watch |  ANIP |
ANI Pharmaceuticals, Inc. · Healthcare | -22.3% | 3.7σ | 3/5 | 344d | $77.32 | Depth |
| Watch |  STOK |
Stoke Therapeutics, Inc. · Healthcare | -21.9% | 3.9σ | 1/5 | 163d | $31.40 | Depth |
| WatchRecovering |  AZN |
AstraZeneca PLC · Healthcare | -21.9% | 3.6σ | 3/5 | 183d | $164.49 | Depth |
| Watch |  ANAB |
AnaptysBio, Inc. · Healthcare | -21.7% | 2.4σ | 2/5 | 107d | $56.69 | Depth |
| WatchRecovering |  RMD |
ResMed Inc. · Healthcare | -21.6% | 0.8σ | 3/5 | 363d | $228.44 | Depth |
| WatchRecovering |  SVRA |
Savara, Inc. · Healthcare | -21.6% | 3.9σ | 3/5 | 251d | $5.49 | Depth |
| Watch |  BCAX |
Bicara Therapeutics Inc. · Healthcare | -21.3% | 3.4σ | 2/5 | 44d | $24.39 | Depth |
| Watch |  VIR |
Vir Biotechnology, Inc. · Healthcare | -21.0% | 3.6σ | 2/5 | 122d | $9.21 | Depth |
| WatchRecovering |  IRON |
Disc Medicine, Inc. · Healthcare | -20.8% | 2.4σ | 2/5 | 255d | $78.84 | Depth |
| Watch |  SUPN |
Supernus Pharmaceuticals, Inc. · Healthcare | -20.5% | 3.6σ | 1/5 | 176d | $47.45 | Depth |
| WatchRecovering |  VKTX |
Viking Therapeutics, Inc. · Healthcare | -20.4% | 2.3σ | 2/5 | 281d | $34.36 | Depth |